Endocrine Abstracts

Objective: An adrenal incidentaloma is discovered in about 3–4% of patients undergoing radiological examination (CT/MRI) of the abdominal region. Current diagnostic algorithms for differentiating between benign and malignant lesions largely depend on imaging studies, which lack in specificity. This often leads to extended radiological follow-up of benign lesions, which is time-consuming, expensive and carries a health risk. It was recently suggested that urinary steroid p...

The finding of an adrenal incidentaloma warrants a careful diagnostic work-up to assess hormonal activity and potential malignancy. Current diagnostic algorithms depend largely on imaging studies, which is time-consuming, expensive and carries a health risk. Urinary steroid profiling using gas chromatography/mass spectrometry (GC/MS) might be a valuable diagnostic test for differentiating benign from malignant adrenal lesions, as adrenocortical carcinomas (ACC) often cause abn...

Background: Patients with secondary adrenal insufficiency show increased risk of cardiovascular disease. Higher doses of glucocorticoid replacement are related to an unfavourable metabolic profile. In the absence of randomized controlled trials assessing the effect of hydrocortisone dose on haemodynamics and blood pressure regulation, we determined effects of a higher vs a lower glucocorticoid replacement dose on blood pressure, the renin-angiotensin-aldosterone system (RAAS) ...